Wnt for adhesion
نویسندگان
چکیده
منابع مشابه
Wnt for adhesion
Wnt for adhesion nt signaling keeps a group of migrating cells together, say Florian Ulrich, Michael Krieg, Carl-Philipp Heisenberg (Max Planck Institute, Dresden, Germany), and colleagues. Wnt achieves this by promoting the recycling of adhesion molecules. Signaling via Wnt11 is needed during vertebrate gastrulation, when the group of cells that will form the axial mesendoderm migrate en masse...
متن کاملThe Wnt signaling pathways and cell adhesion.
In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling pathways affect adhesion and migration via downstream effectors. Canonical Wnt signaling regulates...
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Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
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The epithelial-mesenchymal transition is essential in both embryonic development and the progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been implicated in both processes; clarifying their role will depend on linking them to rearrangements of cellular structure and behavior. beta-Catenin is an essential molecule both in cadherin-mediated cell adhesion and in canonic...
متن کاملβ-Catenin: A Pivot between Cell Adhesion and Wnt Signalling
Mutual adhesion of animal cells is intimately linked to Wnt signaling through a shared component: beta-catenin, or Armadillo in Drosophila. Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1712rr3